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A Cardiovascular Disease Linked Gut Microbial Metabolite

Using untargeted metabolomics (n = 1,162 subjects), the plasma metabolite (m/z = 265.1188) phenylacetylglutamine (PAGln) was discovered and then shown in an independent cohort (n = 4,000 subjects) to be associated with cardiovascular disease (CVD) and incident major adverse cardiovascular events (myocardial infarction, stroke, or death).A gut microbiota derived metabolite, PAGln, was

Semiconductor Engineering Deep Insights For Chip Engineers

Disclaimer:Semiconductor Engineering/Sperling Media Group LLC ely disclaims the adequacy, accuracy, or completeness of any data and shall not be liable for any errors, omissions or other faults in, delays or interruptions in such data, or for any actions taken in reliance thereon.

Category Main Page · Manufacturing, Test · How to Build an Automotive Chip

Thin cloud detection over land using background surface

Finally, we statistically validated the cloud mask results of GOCI from 1 January 2014 to 30 June 2015 over the Northeast Asia region, using spatially and temporally collocated matchup data sets. Table 3 shows the validation results of GOCI cloud detection compared to the CALIPSO VFM images. As mentioned earlier, the official MODIS cloud mask

A first collective validation of global fluvial flood

Flooding is the most frequent and the most damaging of natural disasters globally [].From 19952015, floods affected 2.3 billion people, killing 157 000 [].Fluvial (river) flooding is the most common type of flood event and with over half of the world's population living within 3 km of a freshwater body, it has truly global implications [].

The credibility challenge for global fluvial flood risk

Sep 14, 2016 · Flooding is one of the most damaging natural hazards, accounting for 31% of all economic losses worldwide resulting from natural hazards [].The ten costliest floods between 1980 and 2014 caused an estimated US$187 billion in overall losses (adjusted for inflation) as well as the loss of 13 597 lives [].With the frequency and magnitude of flood disasters projected to increase due to both

Maersk Integrated Container Logistics & Supply Chain

To address a vital need in global trade, A.P. Moller Maersk is developing an integrated cold chain offering that will reduce food waste, minimise complexity for customers and put the business in an even stronger position to tap into the high growth market for perishable goods.

Standard medical nutrition therapy of 25 kcal/kg ideal

Oct 28, 2019 · Aims/Introduction. In Japan, an ideal bodyweight (IBW) calculated by 22 × height (m) 2 has commonly been used in the planning of medical nutrition therapy (MNT). However, there have been concerns regarding calorie deficits in fulfilling resting energy expenditure (REE) for patients with type 2 diabetes undergoing MNT as defined by 25 kcal/kg IBW/day.

A Cardiovascular Disease Linked Gut Microbial Metabolite

A microbially generated metabolite, PAGIn, is associated with cardiovascular disease and death in humans. Studies in animal models provide insights into PAGIn metabolism as well as its effects in driving platelet invasiveness and thrombosis through adrenergic receptors.

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C# DateTime to "YYYYMMDDHHMMSS" format Stack

In .Net Standard 2 you can format DateTime like belows Correlating mol/m^2 with ton and lb? 12 Grimmauld Place Layout iPad Keyboard shortcut to show keyboard shortcuts How can I get rid of drama fatigue as a GM? Why would anyone from Japan be in Northern India in early 1900s?

Cellular and Molecular Probing of Intact Human OrgansCell

Thereby, we revealed structural details of the intact human eye, human thyroid, human kidney, and transgenic pig pancreas at the cellular resolution. Furthermore, we developed a deep learning pipeline to analyze millions of cells in cleared human brain tissues within hours with standard lab computers.

RCSB PDBHomepage

As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.

Guidelines for the use of cell lines in biomedical research

Sep 09, 2014 · Recommendations from the standard should be followed, including the use of at least eight core STR loci and application of match criteria (80% match threshold) to allow for a small amount of genetic drift in some cell lines. The standard can be purchased at the ANSI eStore (American National Standards Institute, 2011). Large numbers of

Home Army Public Health Center

This Web site provides an introduction to the Army Public Health Center, a U.S. Army Medical Department organization. It is intended for interested members of the public, news media, and Army Medical Department professionals and beneficiaries.

Optimized models for design of efficient miR30 based shRNAs

Aug 29, 2012 · Small hairpin RNAs (shRNAs) became an important research tool in cell biology. Reliable design of these molecules is essential for the needs of large functional genomics projects. To optimize the design of efficient shRNAs, we performed comparative, thermodynamic, and correlation analyses of ~18,000 miR30 based shRNAs with known functional efficiencies, derived from the Sensor Assay

BrainMass 24/7 Academic Help

BrainMass is a community of academic subject Experts that provides online tutoring, homework help and Solution Library services across all subjects, to students of

Lamin B2 Levels Regulate Polyploidization of Cardiomyocyte

Polyploid nuclei in heart muscle cells are thought to be a barrier for heart regeneration, but how they are generated is unknown. Han et al. demonstrate that low Lamin B2 levels trigger formation of polyploid nuclei in mouse and human heart muscle cells, which decreases heart regeneration.

Review articlesystemic treatment of hepatocellular

Jul 23, 2018 · This was probably because of the enrolment of patients with more advanced disease in terms of extrahepatic spread, number of intrahepatic lesions, alphaFetoprotein (AFP), and performance status. 21 Hence, sorafenib showed a survival benefit in two independent phase III trials conducted in different geographic regions, and became the standard

Vinyl acetate C4H6O2 PubChem

Two male Wistar Rats exposed to vinyl acetate (stabilized with 0.01% hydroquinone) concentrations varying between 200 and 2000 ppm in closed chambers with an exposure time of 1.4 hr or less demonstrated dose dependent elimination kinetics.The authors concluded that the metabolic pathways became saturated when vinyl acetate exposure levels exceeded 650 ppm (2320 mg/cu m).

:CVIA :Cardiovascular Imaging Asia

Moreover, the time slot required for CCTA becomes unpredictable, which causes substantial inconvenience in scheduling of CT scans. From a technical perspective, cross contamination of contrast in the stress perfusion scan and beta blockers used to optimize CCTA may mask ischemia.

Cryo EM structure of the Shigella type III needle complex

The Type III Secretion Systems (T3SS) needle complex is a conserved syringe shaped protein translocation nanomachine with a mass of about 3.5 MDa essential for the survival and virulence of many Gram negative bacterial pathogens. This system is composed of a

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